Cell Diagram with Platinum Compound Pathways

This detailed cellular diagram maps the intricate journey and impact of platinum compounds within a cell. It illustrates their initial entry, mediated by specific transporters like SLC31A1, and their potential efflux by proteins such as ABCG2 and ABCC2. Inside the cell, these compounds can undergo detoxification processes involving enzymes like GSTT1 and MT1A. Crucially, the platinum compounds enter the nucleus where they interact directly with DNA, causing damage (represented as GG adducts). The cell responds to this DNA damage through multiple sophisticated repair mechanisms, including mismatch repair (involving proteins like MSH2 and MLH1), excision repair (with components such as XRCC1 and ERCC1), and translesional replication (utilizing enzymes like POLH). Proteins like HMGB1 are crucial for damage recognition. Ultimately, the accumulation of unrepaired DNA damage or the activation of these repair pathways can lead to programmed cell death, highlighting the complex cellular responses to these compounds.

platinum - cell - DNA repair - detoxification - pathways - chemotherapy - drug action