Comprehensive Metabolic Pathway of Phenylalanine and Tyrosine Highlighting Genetic Disorders
Phenylalanine and Tyrosine Metabolic Pathway
An insightful diagram illustrating the intricate metabolic pathway of phenylalanine and tyrosine in humans. It details the sequential enzymatic conversions of these amino acids, from phenylalanine's conversion to tyrosine, down through various intermediates like p-hydroxyphenylpyruvate and homogentisate, finally yielding fumarate and acetoacetate. Crucially, the diagram highlights specific points where enzyme deficiencies lead to well-known inherited metabolic disorders, including classical Phenylketonuria (PKU), its new variant, Tyrosinemia types I, II, and III, and Alkaptonuria. Each affected enzyme and the resulting condition are clearly indicated, providing a clear overview of these biochemical pathways and their associated diseases.
